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Plos Pathogens : Mechanisms of Candida Albicans Trafficking to the...

By: Leah E. Cowen

Description : During hematogenously disseminated disease, Candida albicans infects most organs, including the brain. We discovered that a C. albicans vps51D/D mutant had significantly increased tropism for the brain in the mouse model of disseminated disease. To investigate the mechanisms of this enhanced trafficking to the brain, we studied the interactions of wild-type C. albicans and the vps51D/D mutant with brain microvascular endothelial cells in vitro. These studie...

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Plos Pathogens : Loss and Retention of Rna Interference in Fungi a...

By: Joseph Heitman
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Plos Pathogens : the Type I Nadh Dehydrogenase of Mycobacterium Tu...

By: Vojo Deretic

Description : Miller JL, Velmurugan K, Cowan MJ, Briken V (2010) The Type I NADH Dehydrogenase of Mycobacterium Tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-a-Mediated Host Cell Apoptosis.

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Plos Pathogens : Atomic Model of Rabbit Hemorrhagic Disease Virus ...

By: Erica Ollmann Saphire

Description : Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we report a cryo-electron microscopic (cryoEM) reconstruction of wild-type RHDV at 6.5 A° resolution and the crystal structures of the shell (S)...

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Plos Pathogens : Dnase Sda1 Allows Invasive M1T1 Group a Streptoco...

By: Frank R. Deleo

Description : Group A Streptococcus (GAS) has developed a broad arsenal of virulence factors that serve to circumvent host defensemechanisms. The virulence factor DNase Sda1 of the hyperinvasive M1T1 GAS clone degrades DNA-based neutrophil extracellular traps allowing GAS to escape extracellular killing. TLR9 is activated by unmethylated CpG-rich bacterial DNA and enhances innate immune resistance. We hypothesized that Sda1 degradation of bacterial DNA could alter TLR9-m...

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Plos Pathogens : the Epstein-barr Virus G-protein-coupled Receptor...

By: Klaus Fruh
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Plos Pathogens : Host Genetics and Hiv-1 ; the Final Phase, Volume 6

By: Jacques Fellay

Description : This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retro...

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Plos Pathogens : a Timescale for Evolution, Population Expansion, ...

By: Theresa Koehler

Description : Nübel U, Dordel J, Kurt K, Strommenger B, Westh H, et al. (2010) A Timescale for Evolution, Population Expansion, and Spatial Spread of an Emerging Clone of Methicillin-Resistant Staphylococcus Aureus.

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Plos Pathogens : Vaccinia Protein F12 Has Structural Similarity to...

By: Michael Hollinshead

Description : Vaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that binds cargo. F12 and KLC share similar size, pI, hydropathy and cargo-binding tetratricopeptide repeats (TPRs). Moreover, molecular modeling of F12 TPRs upon the crystal structure of KLC2 TPRs showed a striking con...

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Plos Pathogens : Strongyloidiasis and Infective Dermatitis Alter H...

By: William C. Gause
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Plos Pathogens : Molecular Cloning and Characterization of Novel G...

By: Martin Richard
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Plos Pathogens : Plant Virus Ecology, Volume 9

By: Richard C. Condit

Description : This work was supported in part by the National Science Foundation (grant numbers EF-0627108, EPS-0447262, IOS-0950579, and IOS-1157148) and The United States Department of Agriculture (grant number OKLR-2007—01012). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Plos Pathogens : Apicoplast Lipoic Acid Protein Ligase B is Not Es...

By: Daniel Goldberg

Description : Günther S, Wallace L, Patzewitz EM, McMillan PJ, Storm J, Et Al. (2007) Apicoplast lipoic Acid Protein ligase B Is Not Essential For Plasmodium Falciparum.

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Plos Pathogens : a Systematic Analysis of Host Factors Reveals a M...

By: Gao Shou-jiang
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Plos Pathogens : News from the Fungal Front ; Wall Proteome Dynami...

By: Joseph Heitman
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Plos Pathogens : the Aedes Aegypti Toll Pathway Controls Dengue Vi...

By: David David S.Schneider
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Plos Pathogens : Indirect Dna Readout by an H-ns Related Protein ;...

By: Ralph R. Isberg

Description : Ler, a member of the H-NS protein family, is the master regulator of the LEE pathogenicity island in virulent Escherichia coli strains. Here, we determined the structure of a complex between the DNA-binding domain of Ler (CT-Ler) and a 15-mer DNA duplex. CT-Ler recognizes a preexisting structural pattern in the DNA minor groove formed by two consecutive regions which are narrower and wider, respectively, compared with standard B-DNA. The compressed region, ...

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Plos Pathogens : Inhibition of Competence Development, Horizontal ...

By: Debra E. Bessen

Description : Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is initiated, leading to activation of the competence regulon by the response regulator ComE. Genes encoding proteins that are involved in DNA uptake and transformation, as well as virulence, are upregulated. Previous studies have shown that disrupti...

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Plos Pathogens : the Influence of Host and Bacterial Genotype on t...

By: William Bishai
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Plos Pathogens : Contribution of Coagulases Towards Staphylococcus...

By: Ambrose Cheung

Description : The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation o...

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