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Mechanical ventilation

Mechanical ventilation
Diagram of an endotracheal tube used in mechanical ventilation. The tube is inserted into the trachea in order to provide air to the lungs.

A) Endotracheal tube, which sits in the trachea. B) Inflatable Cuff, which facilitates the inflation of the balloon at the end of the tube to allow it to sit securely in the airway. The balloon can also be deflated via this cuff upon extubation. C) Trachea

D) Esophagus
ICD-9 93.90 96.7
OPS-301 code 8-71

In medicine, mechanical ventilation is a method to mechanically assist or replace spontaneous breathing. This may involve a machine called a ventilator or the breathing may be assisted by a registered nurse, physician, physician assistant, respiratory therapist, paramedic, or other suitable person compressing a bag or set of bellows. Mechanical ventilation is termed "invasive" if it involves any instrument penetrating through the mouth (such as an endotracheal tube) or the skin (such as a tracheostomy tube).[1] There are two main modes of mechanical ventilation within the two divisions: positive pressure ventilation, where air (or another gas mix) is pushed into the trachea, and negative pressure ventilation, where air is, in essence, sucked into the lungs.


  • Medical uses 1
  • Associated risk 2
    • Complications 2.1
  • Application and duration 3
    • Negative pressure machines 3.1
    • Positive pressure 3.2
      • Transairway pressure 3.2.1
  • Types of ventilators 4
    • Mechanical ventilators 4.1
  • Breath delivery 5
    • Trigger 5.1
    • Cycle 5.2
    • Limit 5.3
  • Breath exhalation 6
  • Dead space 7
  • Modes of ventilation 8
  • Modification of settings 9
    • Weaning from mechanical ventilation 9.1
  • Respiratory monitoring 10
  • Artificial airways as a connection to the ventilator 11
  • Ventilation formulas 12
    • Alveolar Ventilation 12.1
    • Arterial PaCO2 12.2
    • Alveolar volume 12.3
    • Estimated physiologic shunt equation 12.4
  • History 13
  • References 14
  • External links 15

Medical uses

Respiratory therapist examining a mechanically ventilated patient on an Intensive Care Unit.

Mechanical ventilation is indicated when the patient's spontaneous ventilation is inadequate to maintain life. It is also indicated as prophylaxis for imminent collapse of other physiologic functions, or ineffective gas exchange in the lungs. Because mechanical ventilation serves only to provide assistance for breathing and does not cure a disease, the patient's underlying condition should be correctable and should resolve over time. In addition, other factors must be taken into consideration because mechanical ventilation is not without its complications (see below)

Common medical indications for use include:

Associated risk

BarotraumaPulmonary barotrauma is a well-known complication of positive-pressure mechanical ventilation.[2] This includes pneumothorax, subcutaneous emphysema, pneumomediastinum, and pneumoperitoneum.[2]

Ventilator-associated lung injuryVentilator-associated lung injury (VALI) refers to acute lung injury that occurs during mechanical ventilation. It is clinically indistinguishable from acute lung injury or acute respiratory distress syndrome (ALI/ARDS).[3]

Diaphragm — Controlled mechanical ventilation may lead to a rapid type of disuse atrophy involving the diaphragmatic muscle fibers, which can develop within the first day of mechanical ventilation.[4] This cause of atrophy in the diaphragm is also a cause of atrophy in all respiratory related muscles during controlled mechanical ventilation.[5]

Motility of mucocilia in the airways — Positive pressure ventilation appears to impair mucociliary motility in the airways. Bronchial mucus transport was frequently impaired and associated with retention of secretions and pneumonia.[6]


Mechanical ventilation is often a life-saving intervention, but carries potential complications including pneumothorax, airway injury, alveolar damage, and ventilator-associated pneumonia.[7] Other complications include diaphragm atrophy, decreased cardiac output, and oxygen toxicity. One of the primary complications that presents in patients mechanically ventilated is acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). ALI/ARDS are recognized as significant contributors to patient morbidity and mortality.[8]

In many healthcare systems, prolonged ventilation as part of

  • e-Medicine, article on mechanical ventilation along with technical information.
  • International Ventilator Users Network (IVUN), Resource of information for users of home mechanical ventilation.

External links

  1. ^ GN-13: Guidance on the Risk Classification of General Medical Devices, Revision 1.1. From Health Sciences Authority. May 2014
  2. ^ a b Parker JC, Hernandez LA, Peevy KJ (1993). "Mechanisms of ventilator-induced lung injury". Crit Care Med 21 (1): 131–43.  
  3. ^ "International consensus conferences in intensive care medicine: Ventilator-associated Lung Injury in ARDS. This official conference report was cosponsored by the American Thoracic Society, The European Society of Intensive Care Medicine, and The Societé de Réanimation de Langue Française, and was approved by the ATS Board of Directors, July 1999". Am. J. Respir. Crit. Care Med. 160 (6): 2118–24. December 1999.  
  4. ^ Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, et al. (2008). "Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans". N Engl J Med 358 (13): 1327–35.  
  5. ^ De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, et al. (2002). "Paresis acquired in the intensive care unit: a prospective multicenter study". JAMA 288 (22): 2859–67.  
  6. ^ Konrad F, Schreiber T, Brecht-Kraus D, Georgieff M (1994). "Mucociliary transport in ICU patients". Chest 105 (1): 237–41.  
  7. ^ Hess DR (2011). "Approaches to conventional mechanical ventilation of the patient with acute respiratory distress syndrome". Respir Care 56 (10): 1555–72.  
  8. ^ Hoesch, Robert; Eric Lin; Mark Young; Rebecca Gottesman; Laith Altaweel; Paul Nyquist; Robert Stevens (February 2012). "Acute lung injury in critical neurological illness". Critical care medicine 40 (2): 587–593.  
  9. ^ O'Connor HH (2011). "Prolonged mechanical ventilation: are you a lumper or a splitter?". Respir Care 56 (11): 1859–60.  
  10. ^ Esteban A, Anzueto A, Alía I, Gordo F, Apezteguía C, Pálizas F, et al. (2000). "How is mechanical ventilation employed in the intensive care unit? An international utilization review.". Am J Respir Crit Care Med 161 (5): 1450–8.  
  11. ^ Yang KL, Tobin MJ (May 1991). "A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation". N. Engl. J. Med. 324 (21): 1445–50.  
  12. ^ Tobin MJ (2006). Principles and Practice of Mechanical Ventilation (2nd ed.). McGraw Hill. 
  13. ^ Cook T, Howes B (December 2011). "Supraglottic airway devices: recent advances". Contin Educ Anaesth Crit Care 11 (2): 56–61.  
  14. ^ Carley SD, Gwinnutt C, Butler J, Sammy I, Driscoll P (March 2002). "Rapid sequence induction in the emergency department: a strategy for failure". Emerg Med J 19 (2): 109–13.  
  15. ^ Colice, Gene L (2006). "Historical Perspective on the Development of Mechanical Ventilation". In Martin J Tobin. Principles & Practice of Mechanical Ventilation (2 ed.). New York: McGraw-Hill.  
  16. ^ Chamberlain D (2003). "Never quite there: a tale of resuscitation medicine". Clin Med 3 (6): 573–7.  
  17. ^  


[17] The Roman physician


\frac{Q_{SP}}{Q_T} = \frac{CcO_2 - CaO_2}{5+(CcO_2 - CaO_2)}

Estimated physiologic shunt equation

V_A = V_T - V_f

Alveolar volume

PaCO_2 = \frac{0.863 \times \dot{V}_{CO_2}}{\dot{V}_A}

Arterial PaCO2

\dot{V}_A = \ (V_T - V_{DSphys}) \times f

Alveolar Ventilation

Ventilation formulas

  • Face mask — In resuscitation and for minor procedures under anaesthesia, a face mask is often sufficient to achieve a seal against air leakage. Airway patency of the unconscious patient is maintained either by manipulation of the jaw or by the use of nasopharyngeal or oropharyngeal airway. These are designed to provide a passage of air to the pharynx through the nose or mouth, respectively. Poorly fitted masks often cause nasal bridge ulcers, a problem for some patients. Face masks are also used for non-invasive ventilation in conscious patients. A full face mask does not, however, provide protection against aspiration.
  • Tracheal intubation is often performed for mechanical ventilation of hours to weeks duration. A tube is inserted through the nose (nasotracheal intubation) or mouth (orotracheal intubation) and advanced into the trachea. In most cases, tubes with inflatable cuffs are used for protection against leakage and aspiration. Intubation with a cuffed tube is thought to provide the best protection against aspiration. Tracheal tubes inevitably cause pain and coughing. Therefore, unless a patient is unconscious or anaesthetized for other reasons, sedative drugs are usually given to provide tolerance of the tube. Other disadvantages of tracheal intubation include damage to the mucosal lining of the nasopharynx or oropharynx and subglottic stenosis.
  • Supraglottic airway — a supraglottic airway (SGA) is any airway device that is seated above and outside the trachea, as an alternative to endotracheal intubation. Most devices work via masks or cuffs that inflate to isolate the trachea for oxygen delivery. Newer devices feature esophageal ports for suctioning or ports for tube exchange to allow intubation. Supraglottic airways differ primarily from tracheal intubation in that they do not prevent aspiration. After the introduction of the laryngeal mask airway (LMA) in 1998, supraglottic airway devices have become mainstream in both elective and emergency anesthesia.[13] There are many types of SGAs available including the Esophageal-tracheal Combitube (ETC), Laryngeal tube (LT), and the obsolete Esophageal obturator airway (EOA).
  • Cricothyrotomy — Patients requiring emergency airway management, in whom tracheal intubation has been unsuccessful, may require an airway inserted through a surgical opening in the cricothyroid membrane. This is similar to a tracheostomy but a cricothyrotomy is reserved for emergency access.[14]
  • Tracheostomy — When patients require mechanical ventilation for several weeks, a tracheostomy may provide the most suitable access to the trachea. A tracheostomy is a surgically created passage into the trachea. Tracheostomy tubes are well-tolerated and often do not necessitate any use of sedative drugs. Tracheostomy tubes may be inserted early during treatment in patients with pre-existing severe respiratory disease, or in any patient expected to be difficult to wean from mechanical ventilation, i.e., patients with little muscular reserve.
  • Mouthpiece — Less common interface, does not provide protection against aspiration. There are lipseal mouthpieces with flanges to help hold them in place if patient is unable.

There are various procedures and mechanical devices that provide protection against airway collapse, air leakage, and aspiration:

Artificial airways as a connection to the ventilator

Most of modern ventilators have basic monitoring tools. There are also monitors that work independently of the ventilator, which allow to measure patients after the ventilator has been removed, such as a T tube test.

One of the main reasons why a patient is admitted to an ICU is for delivery of mechanical ventilation. Monitoring a patient in mechanical ventilation has many clinical applications: Enhance understanding of pathophysiology, aid with diagnosis, guide patient management, avoid complications and assessment of trends.[12]

Respiratory mechanics monitor

Respiratory monitoring

The Rapid Shallow Breathing Index (RSBI, the ratio of respiratory frequency to tidal volume (f/VT), previously referred to as the "Tobin Index" after Dr. Martin Tobin of Loyola University Medical Center) is one of the best studied and most commonly used weaning predictors, with no other predictor having been shown to be superior. It was described in a prospective cohort study of mechanically ventilated patients which found that a RSBI > 105 breaths/min/L was associated with weaning failure, while a RSBI < 105 breaths/min/L predicted weaning success with a sensitivity, specificity, positive predictive value and negative predictive value of 97%, 64%, 78%, 95% respectively.[11]

Withdrawal from mechanical ventilation—also known as weaning—should not be delayed unnecessarily, nor should it be done prematurely. Patients should have their ventilation considered for withdrawal if they are able to support their own ventilation and oxygenation, and this should be assessed continuously. There are several objective parameters to look for when considering withdrawal, but there are no specific criteria that generalizes to all patients.

Weaning from mechanical ventilation

When using 100% O2 (FiO
1.00), the degree of shunting is estimated by subtracting the measured PaO
(from an arterial blood gas) from 700 mmHg. For each difference of 100 mmHg, the shunt is 5%. A shunt of more than 25% should prompt a search for the cause of this hypoxemia, such as mainstem intubation or pneumothorax, and should be treated accordingly. If such complications are not present, other causes must be sought after, and positive end-expiratory pressure (PEEP) should be used to treat this intrapulmonary shunt. Other such causes of a shunt include:

In adults when 100% Oxygen (O2) (1.00 FiO
) is used initially, it is easy to calculate the next FiO
to be used and easy to estimate the shunt fraction. The estimated shunt fraction refers to the amount of oxygen not being absorbed into the circulation. In normal physiology, gas exchange (oxygen/carbon dioxide) occurs at the level of the alveoli in the lungs. The existence of a shunt refers to any process that hinders this gas exchange, leading to wasted oxygen inspired and the flow of un-oxygenated blood back to the left heart (which ultimately supplies the rest of the body with unoxygenated blood).

Modification of settings

Mechanical ventilation utilizes several separate systems for ventilation referred to as the mode. Modes come in many different delivery concepts but all modes fall into one of three categories; volume-cycled, pressure-cycled, spontaneously cycled. In general, the selection of which mode of mechanical ventilation to use for a given patient is based on the familiarity of clinicians with modes and the equipment availability at a particular institution.[10]

Modes of ventilation

\frac{V_D}{V_T} = \frac{PaCO_2 - P\bar{E}CO_2}{PaCO_2}

Simplified version

V_{Dmech} = V_T - V_{Dphys} - \frac{PaCO2(V_T - V_D - V_{Dmech})}{P_{ACO_{2}}}

Example of calculation for mechanical dead space

Mechanical dead space is defined as the volume of gas re-breathed as the result of use in a mechanical device.

Dead space

Exhalation in mechanical ventilation is almost always completely passive. The ventilator's expiratory valve is opened, and expiratory flow is allowed until the baseline pressure (PEEP) is reached. Expiratory flow is determined by patient factors such as compliance and resistance.

Breath exhalation

Limit is how the breath is controlled. Breaths may be limited to a set maximum circuit pressure or a set maximum flow.


The cycle is what causes the breath to transition from the inspiratory phase to the exhalation phase. Breaths may be cycled by a mechanical ventilator when a set time has been reached, or when a preset flow or percentage of the maximum flow delivered during a breath is reached depending on the breath type and the settings. Breaths can also be cycled when an alarm condition such as a high pressure limit has been reached, which is a primary strategy in pressure regulated volume control.


The trigger is what causes a breath to be delivered by a mechanical ventilator. Breaths may be triggered by a patient taking their own breath, a ventilator operator pressing a manual breath button, or by the ventilator based on the set breath rate and mode of ventilation.


Breath delivery

  • Transport ventilators — These ventilators are small and more rugged, and can be powered pneumatically or via AC or DC power sources.
  • Intensive-care ventilators — These ventilators are larger and usually run on AC power (though virtually all contain a battery to facilitate intra-facility transport and as a back-up in the event of a power failure). This style of ventilator often provides greater control of a wide variety of ventilation parameters (such as inspiratory rise time). Many ICU ventilators also incorporate graphics to provide visual feedback of each breath.
  • Neonatal ventilators — Designed with the preterm neonate in mind, these are a specialized subset of ICU ventilators that are designed to deliver the smaller, more precise volumes and pressures required to ventilate these patients.
  • Positive airway pressure ventilators (PAP) — These ventilators are specifically designed for non-invasive ventilation. This includes ventilators for use at home for treatment of chronic conditions such as sleep apnea or COPD.

Mechanical ventilators typically require power by a battery or a wall outlet (DC or AC) though some ventilators work on a pneumatic system not requiring power.

Mechanical ventilators

Ventilators come in many different styles and method of giving a breath to sustain life. There are manual ventilators such as bag valve masks and anesthesia bags that require the users to hold the ventilator to the face or to an artificial airway and maintain breaths with their hands. Mechanical ventilators are ventilators not requiring operator effort and are typically computer-controlled or pneumatic-controlled.

SMART BAG MO Bag-Valve-Mask Resuscitator

Types of ventilators

  • PTA =Transairway pressure
  • PAO = Pressure at airway opening
  • PALV = Pressure in alveoli
P_{TA} = (P_{AO}) - (P_{ALV})

Transairway pressure

Positive-pressure ventilators work by increasing the patient's airway pressure through an endotracheal or tracheostomy tube. The positive pressure allows air to flow into the airway until the ventilator breath is terminated. Then, the airway pressure drops to zero, and the elastic recoil of the chest wall and lungs push the tidal volume — the breath-out through passive exhalation.

The design of the modern positive-pressure ventilators were based mainly on technical developments by the military during World War II to supply oxygen to fighter pilots in high altitude. Such ventilators replaced the iron lungs as safe endotracheal tubes with high-volume/low-pressure cuffs were developed. The popularity of positive-pressure ventilators rose during the polio epidemic in the 1950s in Scandinavia and the United States and was the beginning of modern ventilation therapy. Positive pressure through manual supply of 50% oxygen through a tracheostomy tube led to a reduced mortality rate among patients with polio and respiratory paralysis. However, because of the sheer amount of man-power required for such manual intervention, mechanical positive-pressure ventilators became increasingly popular.

Neonatal mechanical ventilator

Positive pressure

Today, negative pressure mechanical ventilators are still in use, notably with the polio wing hospitals in England such as St Thomas' Hospital in London and the John Radcliffe in Oxford. The prominent device used is a smaller device known as the cuirass. The cuirass is a shell-like unit, creating negative pressure only to the chest using a combination of a fitting shell and a soft bladder. Its main use is in patients with neuromuscular disorders that have some residual muscular function. However, it was prone to falling off and caused severe chafing and skin damage and was not used as a long-term device. In recent years this device has re-surfaced as a modern polycarbonate shell with multiple seals and a high-pressure oscillation pump in order to carry out biphasic cuirass ventilation.

In the iron lung by means of a pump, the air is withdrawn mechanically to produce a vacuum inside the tank, thus creating negative pressure. This negative pressure leads to expansion of the chest, which causes a decrease in intrapulmonary pressure, and increases flow of ambient air into the lungs. As the vacuum is released, the pressure inside the tank equalizes to that of the ambient pressure, and the elastic coil of the chest and lungs leads to passive exhalation. However, when the vacuum is created, the abdomen also expands along with the lung, cutting off venous flow back to the heart, leading to pooling of venous blood in the lower extremities. There are large portholes for nurse or home assistant access. The patients can talk and eat normally, and can see the world through a well-placed series of mirrors. Some could remain in these iron lungs for years at a time quite successfully.

While the exchange of oxygen and carbon dioxide between the bloodstream and the pulmonary airspace works by diffusion and requires no external work, air must be moved into and out of the lungs to make it available to the gas exchange process. In spontaneous breathing, a negative pressure is created in the pleural cavity by the muscles of respiration, and the resulting gradient between the atmospheric pressure and the pressure inside the thorax generates a flow of air.

The iron lung, also known as the Drinker and Shaw tank, was developed in 1929 and was one of the first negative-pressure machines used for long-term ventilation. It was refined and used in the 20th century largely as a result of the polio epidemic that struck the world in the 1940s. The machine is, in effect, a large elongated tank, which encases the patient up to the neck. The neck is sealed with a rubber gasket so that the patient's face (and airway) are exposed to the room air.

An iron lung

Negative pressure machines

It can be used as a short-term measure, for example during an operation or critical illness (often in the setting of an intensive-care unit). It may be used at home or in a nursing or rehabilitation institution if patients have chronic illnesses that require long-term ventilatory assistance. Due to the anatomy of the human pharynx, larynx, and esophagus and the circumstances for which ventilation is needed, additional measures are often required to secure the airway during positive-pressure ventilation in order to allow unimpeded passage of air into the trachea and avoid air passing into the esophagus and stomach. The common method is by insertion of a tube into the trachea: intubation, which provides a clear route for the air. This can be either an endotracheal tube, inserted through the natural openings of mouth or nose, or a tracheostomy inserted through an artificial opening in the neck. In other circumstances simple airway maneuvres, an oropharyngeal airway or laryngeal mask airway may be employed. If the patient is able to protect his/her own airway and non-invasive ventilation or negative-pressure ventilation is used then an airway adjunct may not be needed.

Application and duration


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