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Cajal body

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Title: Cajal body  
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Subject: Cell nucleus, Telomeres, Cajal, Cell anatomy, Organelles
Collection: Cell Anatomy, Cell Nucleus, Nuclear Substructures, Organelles, Telomeres
Publisher: World Heritage Encyclopedia

Cajal body

Image of four oval-shaped blue nuclei containing small green dots representing Cajal bodies.
Nuclei of mouse cells (blue) containing Cajal bodies (green) visualized by fusion of p80/Coilin protein to GFP.

Cajal bodies (CBs) are spherical sub-organelles of 0.3-1.0 µm in diameter found in the nucleoplasm. They were first reported by Santiago Ramón y Cajal in 1903, who called them nucleolar accessory bodies due to their association with the nucleoli in neuronal cells.[1] They were rediscovered by electron microscopists and named coiled bodies, according to their appearance as coiled threads on EM images, and later renamed after their discoverer.[2] Research on CBs was accelerated after discovery and cloning of the marker protein p80/Coilin.[3] CBs have been implicated in RNA-related metabolic processes such as snRNPs biogenesis, maturation and recycling, histone mRNA processing and telomere maintenance. CBs assemble RNA which is used by telomerase to add nucleotides to the ends of telomeres.[4]


  • History 1
  • Localization 2
  • CBs and cell cycle 3
  • Functions 4
  • References 5


CBs were initially discovered by neurobiologist Santiago Ramón y Cajal in 1903 as small argyrophilic spots in nuclei of silver-stained neuronal cells. Because of their close association with nucleoli he named them nucleolar accessory bodies. Later on, they were forgotten and rediscovered multiple times independently which led to a state where scientists from different research fields used different names for the same structure. Names used for CBs included "spere organelles", "Binnenkörper", "nucelolar bodies" or "coiled bodies". The name coiled bodies comes from observation of electron microscopists Monneron and Bernhard. They described bodies as aggregates composed of coiled threads with thickness of 400-600 Å. When using higher magnification, they appear as tiny, 50 Å thick fibrils irregularly twisted along the axis of the threads. The bodies were even predicted to consist of ribonucleoproteins since treatment of cells with protease and RNase together, but not alone, caused dramatic changes to the structure of CBs.[5]


Cajal bodies are only found in nuclei of plant, yeast, and animal cells. The cells are usually demonstrating high levels of transcriptional activity, including cells that are rapidly dividing.[6]

CBs and cell cycle

They are about 0.1-2.0 micrometres and are found one to five per nucleus. The number varies in different types of cells and over the cell cycle. Maximum number is reached in mid G1 phase and towards G2 they become larger and their number decreases. CBs disassemble during the M phase and reappear again later in G1 phase. Cajal bodies are possibly sites of assembly or modification of the transcription machinery of the nucleus.[7]


CBs are bound to the nucleolus by coilin proteins. P80-coilin is a specific marker for coiled bodies,[8] and demonstrates these bodies tend to be associated with the nucleolus when cells are not dividing.

CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs), possibly indicating that they function to modify RNA after it has been transcribed from DNA.[9] Experimental evidence indicates that CBs contribute to the biogenesis of telomerase enzyme, and assist in subsequent transport of telomerase to telomeres.[10][11]


  1. ^ Cajal SR (1903). "Un sencillo metodo de coloracion selectiva del reticulo protoplasmico y sus efectos en los diversos organos nerviosos de vertebrados e invertebrados". Trab Lab Investig Biol Univ Madr 2: 129–221. 
  2. ^ Gall JG, Bellini M, Wu Z, Murphy C (December 1999). "Assembly of the Nuclear Transcription and Processing Machinery: Cajal Bodies (Coiled Bodies) and Transcriptosomes". Mol. Biol. Cell 10 (12): 4385–402.  
  3. ^ Andrade LE, Chan EK, Raska I, Peebles CL, Roos G, Tan EM (June 1991). "Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin". J. Exp. Med. 173 (6): 1407–19.  
  4. ^ Wright, W.E., Zhao, Y.; Abreu, E.; Kim, J.; Stadler, G.; Eskiocak, U.; Terns, M.P.; Terns, R.M.; Shay, J.W. (6 May 2011). "Processive and Distributive Extension of Human Telomeres by Telomerase Under Homeostatic and Non-equilibrium Conditions". Molecular Cell 42 (3): 297–307.  
  5. ^ Monneron A, Bernhard W (May 1969). "Fine structural organization of the interphase nucleus in some mammalian cells". J. Ultrastruct. Res. 27 (3): 266–88.  
  6. ^ Ogg SC, Lamond A (2002). "Cajal bodies and coilin—moving towards function". J Cell Biol 159 (1): 17–21.  
  7. ^ Cremer T, Cremer C (2001). "Chromosome territories, nuclear architecture and gene regulation in mammalian cells". Nat Rev Genet 2 (4): 292–301.  
  8. ^ Raska I, Ochs RL, Andrade LE, et al. (1990). "Association between the nucleolus and the coiled body". J. Struct. Biol. 104 (1–3): 120–7.  
  9. ^ Nizami Z, Deryusheva S, Gall JG (2010). "The Cajal body and histone locus body". COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY 2 (7): a000653.  
  10. ^ Jády BE, Richard P, Bertrand E, Kiss T (2006). "Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres".  
  11. ^ Tomlinson RL, Ziegler TD, Supakorndej T, Terns RM, Terns MP (2006). "Cell cycle-regulated trafficking of human telomerase to telomeres".  
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