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Cenph

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Title: Cenph  
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Cenph

Centromere protein H
Identifiers
Symbols  ; NNF1; PMF1
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
CENP-H
Identifiers
Symbol CENP-H
Pfam PF05837
InterPro IPR008426

Centromere protein H is a protein that in humans is encoded by the CENPH gene.[1][2][3]

Function

[5] CENP-H contains a coiled-coil structure and a nuclear localisation signal.[5]

Studies show that CENP-H may be associated with certain human cancers.[6][7]

CENP-H shows sequence similarity to the Schizosaccharomyces pombe kinetochore protein Fta3 which is a subunit of the Sim4 complex. This complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, Fta3 and Fta4 associate with the central core and inner repeat region of the centromere.[8]

Other Protein Interactions

CENPH has also been shown to interact with KIAA0090.[9] The significance of this interaction is unclear.

References

  1. ^
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  4. ^
  5. ^ a b
  6. ^
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Further reading

This article incorporates text from the public domain Pfam and InterPro IPR008426

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