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Title: Diterpene  
Author: World Heritage Encyclopedia
Language: English
Subject: Andrographolide, Stemarene, Guanacastepene A, Kahweol, Stemodene
Collection: Diterpenes
Publisher: World Heritage Encyclopedia


Geranylgeranyl pyrophosphate, the starting material for the biosynthesis of diterpenes

Diterpenes are a class of chemical compounds composed of two terpene units with the molecular formula C20H36; they may also be thought of as consisting of six isoprene units. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary intermediate. Diterpenes form the basis for biologically important compounds such as retinol, retinal, and phytol. They are known to be antimicrobial and antiinflammatory.


  • Diterpene structures 1
  • Diterpeneoids 2
    • Taxanes 2.1
  • See also 3
  • Other 4
  • References 5

Diterpene structures

Taxadiene: a tricyclic diterpene

As with most terpenes a huge number of potential structures exists, which may be broadly divided according to the number of rings present.

Number of rings Examples
0 Phytane
1 Cembrene A
2 Sclarene, Labdane
3 Abietane, Taxadiene
4 Stemarene, Stemodene


Retinol: one of the animal forms of vitamin A
Phytol: usedin the biosynthesis of vitamin E and vitamin K1

Diterpenes are formally defined as being hydrocarbons and thus contain no heteroatoms. Functionalized structures should instead be called diterpeneoids, although in scientific literature the two terms are often used interchangeably. Although a wide range of terpene structures exist few of them are biologically significant, by contrast diterpeneoids possess a rich pharmacology and include important compounds such as retinol and phytol.


Taxanes are class of diterpeneoids featuring a taxadiene core. They are produced by plants of the genus Taxus (yew trees) and are widely used as chemotherapy agents.[1]

See also



  1. ^ Rowinsky, MD, Eric K. (February 1997). "THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS". Annual Review of Medicine 48 (1): 353–374.  
  2. ^ The chemistry of Dodonaea spp. VIII. Isolation and crystal structure of a diterpene acid from Dodonaea petiolaris. PR Jefferies, TG Payne, CL Raston and AH White, Australian Journal of Chemistry 34(5) 1001 - 1007
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