World Library  
Flag as Inappropriate
Email this Article

Gerty Cori

Article Id: WHEBN0000252442
Reproduction Date:

Title: Gerty Cori  
Author: World Heritage Encyclopedia
Language: English
Subject: Nobel Prize in Physiology or Medicine, Carl Ferdinand Cori, Rosalyn Sussman Yalow, National Women's Hall of Fame, List of Nobel laureates by university affiliation
Collection: 1896 Births, 1957 Deaths, American Biochemists, American Nobel Laureates, American People of Czech-Jewish Descent, American Physiologists, American Roman Catholics, American Women Scientists, Austrian Biochemists, Austrian Emigrants to the United States, Austrian Nobel Laureates, Austrian Physiologists, Austrian Women Scientists, Charles University in Prague Alumni, Converts to Christianity from Judaism, Converts to Roman Catholicism from Judaism, Czech Jews, Czech Nobel Laureates, Fellows of the American Academy of Arts and Sciences, Jewish American Scientists, Jewish Chemists, Members of the United States National Academy of Sciences, Nobel Laureates in Physiology or Medicine, People from Buffalo, New York, People from Prague, Recipients of the Garvan–olin Medal, Washington University in St. Louis Faculty, Women Biochemists, Women Nobel Laureates, Women Physiologists
Publisher: World Heritage Encyclopedia

Gerty Cori

Gerty Cori
Gerty Cori in 1947
Born Gerty Theresa Radnitz
(1896-08-15)August 15, 1896
Prague, Austro-Hungarian Empire
Died October 26, 1957(1957-10-26) (aged 61)
Glendale, Missouri, USA
Cause of death Myelosclerosis
Residence American
Other names Gerty Theresa Cori
Alma mater Karl-Ferdinands-Universität in Prague
Occupation Biochemist
Known for Extensive research on carbohydrate metabolism; described the Cori cycle; identified Glucose 1-phosphate
Spouse(s) Carl Ferdinand Cori (m. 1920–57)
Awards Many awards and recognitions, including Nobel Prize in Physiology or Medicine (1947)
Garvan–Olin Medal (1948)
Gerty Cori with her husband and fellow-Nobelist, Carl Ferdinand Cori, in 1947.[1]

Gerty Theresa Cori (née Radnitz; August 15, 1896 – October 26, 1957) was a Czech-American biochemist who became the third woman—and first American woman—to win a Nobel Prize in science, and the first woman to be awarded the Nobel Prize in Physiology or Medicine.

Cori was born in Prague (then in the Austro-Hungarian Empire, now the Czech Republic). Growing up at a time when women were marginalized in science and allowed few educational opportunities, she gained admittance to medical school, where she met her future husband Carl Ferdinand Cori; upon their graduation in 1920, they married. Because of deteriorating conditions in Europe, the couple emigrated to the United States in 1922. Gerty Cori continued her early interest in medical research, collaborating in the laboratory with Carl. She published research findings coauthored with her husband, as well as publishing singly. Unlike her husband, she had difficulty securing research positions, and the ones she obtained provided meager pay. Her husband insisted on continuing their collaboration, though he was discouraged from doing so by the institutions that employed him.

With her husband Carl and Argentine physiologist Bernardo Houssay, Gerty Cori received the Nobel Prize in 1947 for the discovery of the mechanism by which glycogen—a derivative of glucose—is broken down in muscle tissue into lactic acid and then resynthesized in the body and stored as a source of energy (known as the Cori cycle). They also identified the important catalyzing compound, the Cori ester. In 2004, both Gerty and Carl Cori were designated a National Historic Chemical Landmark in recognition of their work in clarifying carbohydrate metabolism.[2]

In 1957, Gerty Cori died after a ten-year struggle with myelosclerosis. She remained active in the research laboratory until the end. She received recognition for her achievements through multiple awards and honors. The Cori crater on the Moon and the Cori crater[3] on Venus are named after her.


  • Life and work 1
  • Awards and recognitions 2
  • Final years 3
  • See also 4
  • References 5
  • Further reading 6
  • External links 7

Life and work

Gerty Theresa Radnitz was born into a Jewish family in Prague in 1896. Her father, Otto Radnitz, was a chemist who became manager of sugar refineries after inventing a successful method for refining sugar. Her mother, Martha, a friend of Franz Kafka, was a culturally sophisticated woman.[2] Gerty was tutored at home before enrolling in a Lyceum for girls, and at the age of 16 she decided she wanted to be a medical doctor. Her uncle, a professor of pediatrics, encouraged her to attend medical school, so she studied for and passed the University entrance examination. She was admitted to the medical school of the Karl-Ferdinands-Universität in Prague in 1914 and was awarded a Doctorate in Medicine in 1920. While studying she met Carl Cori who was immediately attracted to her charm, vitality, sense of humor and her love of the outdoors and mountain climbing.[4] They married in 1920 following graduation. Gerty converted to Catholicism, enabling her and Carl to marry in the Roman Catholic Church.[5][6] They moved to Vienna, Austria, where Gerty spent the next two years at the Carolinen Children's Hospital, and her husband worked in a laboratory.[4] While at the hospital, Gerty Cori worked on the pediatrics unit and conducted experiments in temperature regulation, comparing temperatures before and after thyroid treatment, and published papers on blood disorders.[2] Life was difficult following World War I, and Gerty suffered from xerophthalmia caused by severe malnutrition due to food shortages. These problems, in conjunction with the increasing anti-Semitism, contributed to the Coris' decision to leave Europe.[7]

In 1922, the Coris both immigrated to the United States (Gerty six months after Carl because of difficulty in obtaining a position there) to pursue medical research at the "State Institute for the Study of Malignant Diseases" (now the Roswell Park Cancer Institute) in Buffalo, New York. In 1928, they became naturalized citizens of the United States.[8][9]

She was constantly in the laboratory, where we two worked alone. We washed our own laboratory glassware and she would occasionally complain bitterly to Carl about not having any dishwashing help. When she tired, she would retire to her small office adjoining the laboratory, where she would rest on a small cot. She smoked incessantly and dropped cigarette ashes constantly... .

Joseph Larner[4]

Although the Coris were discouraged from working together at Roswell, they continued to do so, specializing in investigating carbohydrate metabolism. They were particularly interested in how glucose is metabolized in the human body and the hormones that regulate this process.[4] They published fifty papers while at Roswell, with first author status going to the one who had done most of the research for a given paper. Gerty Cori published eleven articles as the sole author. In 1929, they proposed the theoretical cycle that later won them the Nobel Prize, the Cori cycle.[8] The cycle describes how the human body uses chemical reactions to break some carbohydrates such as glycogen in muscle tissue into lactic acid, while synthesizing others.[7]

The Coris left Roswell in 1931 after publishing their work on carbohydrate metabolism. A number of universities offered Carl a position but refused to hire Gerty. Gerty was informed during one university interview that it was considered "unamerican" for a married couple to work together.[2] They moved to St. Louis, Missouri in 1931, where Carl had been offered a research position at Washington University School of Medicine. Despite her research background, Gerty was only offered a position as a research associate at a salary one tenth of that received by her husband;[10] she was warned that she might harm her husband's career.[8] In 1943, she was made an associate professor of Research Biological Chemistry and Pharmacology. Months before she won the Nobel Prize, she was promoted to full professor, a post she held until her death in 1957.[11]

They continued their collaboration at Washington University. While working with minced frog muscle, they discovered an intermediate compound that enabled the breakdown of glycogen, called glucose 1-phosphate, now known as the Cori ester.[7] They established the compound's structure, identified the enzyme phosphorylase that catalyzed its chemical formation, and showed that the Cori ester is the beginning step in the conversion of the carbohydrate glycogen into glucose (large amounts of which are found in the liver).[2] It can also be the last step in the conversion of blood glucose to glycogen, as it is a reversible step.[12] Gerty Cori also studied glycogen storage disease, identifying at least four forms, each related to a particular enzymatic defect.[13] She was the first to show that a defect in an enzyme can be the cause of a human genetic disease.[14]

Gerty and Carl Cori collaborated on most of their work, including that which won them the 1947 Nobel Prize in Physiology or Medicine "for their discovery of the course of the catalytic conversion of glycogen". They received one half the prize, the other half going to the Argentinian physiologist, Bernardo Houssay "for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar".[15] Their work continued to clarify the mechanisms of carbohydrate metabolism, advancing understanding of the reversible conversion of sugars and starch, findings which proved crucial in the development of treatments for diabetics.[2]

Awards and recognitions

Despite rampant gender discrimination and nepotism rules, she never stopped pursuing her lifelong interest in medical research. Brilliant and quick-witted, Cori was a superb experimentalist as well as a perfectionist[16]

In 1947 Gerty Cori became the third woman—and the first American woman—to win a Nobel Prize in science, the previous recipients being Marie Curie and Irène Joliot-Curie. She was the first woman to be awarded the Nobel Prize in Physiology or Medicine.[17] She was elected a Fellow of the American Academy of Arts and Sciences in 1953.[18]

The crater Cori on the Moon is named after her.[19] So is the Cori crater on Venus.[20] She also shares a star with Carl on the St. Louis Walk of Fame.[21]

Cori was honored by the release of a US Postal Service stamp in April, 2008.[22] The 41-cent stamp was reported by the Associated Press to have a printing error in the chemical formula for glucose-1-phosphate (Cori ester). The stamp is being distributed despite the error.[23] Her description reads: "Biochemist Gerty Cori (1896–1957), in collaboration with her husband, Carl, made important discoveries—including a new derivative of glucose—that elucidated the steps of carbohydrate metabolism and contributed to the understanding and treatment of diabetes and other metabolic diseases. In 1947, the couple was award a half share of the Nobel Prize in Physiology or Medicine."[24] The other scientists on the "American Scientists" sheet include Linus Pauling, chemist, Edwin Hubble, astronomer, and John Bardeen, physicist.

In 1948, Cori was awarded the Garvan-Olin Medal, an award that recognizes distinguished work in chemistry by American women chemists.[25] She was appointed by President Harry S. Truman as board member of the National Science Foundation, a position she held until her death.[11] She was elected to the National Academy of Sciences, the fourth woman so honored.[26]

In 1949 she was awarded the Iota Sigma Pi National Honorary Member for her significant contribution.[27]

In 2004 the research of Gerti and Carl Cori on carbohydrate metabolism was recognized by the American Chemical Society as a National Historic Chemical Landmark at the Washington University School of Medicine.[2]

Final years

Just before winning the Nobel prize and while they were on a mountain climbing trip, the Coris learned that Gerty Cori was ill with myelosclerosis, a fatal disease of the bone marrow. She struggled for ten years with the illness while continuing her scientific work; only in the final months did she let up. In 1957, she died in her home.[2] She was survived by her husband and their only child, Tom Cori who married the daughter of conservative activist Phyllis Schlafly.[7][28][29]

See also


  1. ^ "Gerty Theresa Radnitz Cori (1896-1957) and Carl Ferdinand Cori (1896-1984) 1947". Smithsonian Institution Archives. Smithsonian Institution. Retrieved 23 July 2013. 
  2. ^ a b c d e f g h "Carl and Gerti Cori and Carbohydrate Metabolism".  
  3. ^
  4. ^ a b c d Larner, Joseph (1992). "Gerty Theresa Cori" (PDF). National Academy of Sciences. pp. 113, 124, 125. Retrieved 17 June 2010. 
  5. ^
  6. ^
  7. ^ a b c d Chemical Heritage Foundation. "Flying, Hopping and Rolling". Retrieved 17 June 2010. 
  8. ^ a b c National Library of Medicine. "Dr. Gerty Theresa Radnitz Cori". Retrieved 17 June 2010. 
  9. ^ "Nobel Lectures – Physiology or Medicine 1942–1962". Elsevier Publishing Company. 1964. Retrieved 17 June 2010. 
  10. ^ Washington University School of Medicine, St. Louis, Missouri. "Gerty Theresa Cori (1896–1957)". Bernard Becker Medical Library. Retrieved 17 June 2010. 
  11. ^ a b Washington University School of Medicine. "Gerty Theresa Cori (1896-1957)". Bernard Becker Medical Library. Retrieved 24 June 2010. 
  12. ^ "Carl Ferdinand & Gerty Theresa Cori". Retrieved 17 June 2010. 
  13. ^ Rothenberg, Marc (2000). The history of science in the United States : an encyclopedia ([Online-Ausg.]. ed.). New York: Garland.  
  14. ^ Smeltzer, Ronald K. (2013). Extraordinary Women in Science & Medicine: Four Centuries of Achievement. The Grolier Club. 
  15. ^ "The Nobel Prize in Physiology or Medicine 1947". Retrieved 17 June 2010. 
  16. ^ Washington University School of Medicine. "Gerty Theresa Cori". Bernard Becker Medical Library. Retrieved 17 June 2010. 
  17. ^ "Facts on the Nobel Prize in Physiology or Medicine". Retrieved 22 June 2010. 
  18. ^ "Book of Members, 1780–2010: Chapter C" (PDF). American Academy of Arts and Sciences. Retrieved July 29, 2014. 
  19. ^ "Gazetteer of Planetary Nomenclature". Retrieved 17 June 2010. 
  20. ^ "Cori House - Cori Crater - Extraterrestrial Locations on". Retrieved 7 February 2014. 
  21. ^ St. Louis Walk of Fame. "St. Louis Walk of Fame Inductees". Retrieved 17 June 2010. 
  22. ^ Keim, Brandon (January 10, 2008). "U.S. Postal Service Gets Scientific With New Stamps". Retrieved 17 June 2010. 
  23. ^ Associated Press (January 15, 2008). "Stamp Honoring Biochemist Bears Error". Fox News. Retrieved 17 June 2010. 
  24. ^ United States Postal Service (March 6, 2008). "Four Legends of American Science Now on U.S. Postage Stamps". Archived from the original on March 6, 2010. Retrieved 17 June 2010. 
  25. ^ "Francis P. Garvan-John M. Olin Medal". American Chemistry Society. Retrieved 17 June 2010. 
  26. ^ Gardner, A. L. (1997). "Gerty Cori, Biochemist, 1896-1957" (PDF). Women Life Scientists: Past, Present, and Future – Connecting Role Models to the Classroom Curriculum. American Physiological Society. Retrieved 24 June 2010. 
  27. ^ "PROFESSIONAL AWARDS". Iota Stigma Pi: National Honor Society for Women in Chemistry. Retrieved 16 December 2014. 
  28. ^ "Nobels All Around". Retrieved 2012-09-23. 
  29. ^ "Anne Cori". Retrieved 2012-09-23. 

Further reading

  • Leroy, Francis (2003). A century of Nobel Prizes recipients: chemistry, physics, and medicine. CRC Press.  
  • McGrayne, Sharon Bertsch (2001). Nobel Prize Women in Science: Their Lives, Struggles and Momentous Discoveries. National Academy Press.  
  • Opfell, Olga S (1978). The Lady Laureates : Women Who Have Won the Nobel Prize. Metuchen, N.J. & London: Scarecrow Press, Inc. pp. 183–193.  

External links

  • Carl and Gerti Cori and Carbohydrate Metabolism from American Chemical Society National Historic Chemical Landmarks
  • “Glories of the Human Mind” by Gerty Cori
  • Bernardo A. Houssay Memorial to Gerty Theresa Cori
  • Gerty Cori Memorabilia
  • Nobel lecture by Carl Cori and Gerty Cori
  • National Academy of Sciences Biographical Memoir
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.