World Library  
Flag as Inappropriate
Email this Article

HIV-associated lipodystrophy

Article Id: WHEBN0021894516
Reproduction Date:

Title: HIV-associated lipodystrophy  
Author: World Heritage Encyclopedia
Language: English
Subject: Management of HIV/AIDS, HIV Drug Resistance Database, HIV-affected community, HIV-associated pruritus, HIV/AIDS in the United Arab Emirates
Collection: Conditions of the Subcutaneous Fat
Publisher: World Heritage Encyclopedia
Publication
Date:
 

HIV-associated lipodystrophy

HIV-associated lipodystrophy
Classification and external resources
MeSH D039682

HIV-associated lipodystrophy is a condition characterized by loss of subcutaneous fat associated with infection with HIV.[1]:497

Contents

  • Cause 1
    • Evidence implicating anti-retroviral medications 1.1
    • Evidence implicating HIV infection alone 1.2
  • Presentations include 2
  • Prognosis 3
  • See also 4
  • References 5

Cause

The exact mechanism of HIV-associated lipodystrophy is not fully elucidated. There is evidence indicating both that it can be caused by anti-retroviral medications and that it can be caused by HIV infection in the absence of anti-retroviral medication.

Evidence implicating anti-retroviral medications

On the one hand, lipodystrophy seems to be mainly due to HIV-1 protease inhibitors. Interference with lipid metabolism is postulated as pathophysiology. Also, the development of lipodystrophy is associated with specific nucleoside reverse transcriptase inhibitors (NRTI). Mitochondrial toxicity is postulated to be involved in the pathogenesis associated with NRTI.[2]

Evidence implicating HIV infection alone

On the other hand, there is evidence that HIV-1 infection on its own contributes to the development of the lipodystrophic phenotype by interfering with some key genes of adipocyte differentiation and mitochondrial function on patients which have not received antiretroviral treatment.[3]

Presentations include

HIV-associated lipodystrophy commonly presents with fat loss in face, buttocks, arms and legs.

There is also fat accumulation in various body parts. Patients often present with "buffalo hump"-like fat deposits in their upper backs. Breast size of patients (both male and female) tends to increase. In addition, patients develop abdominal obesity.

Prognosis

Reversion of lipodystrophy does not occur after withdrawal of protease inhibitors.[2]

See also

References

  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier.  
  2. ^ a b Martinez E, Mocroft A, García-Viejo MA, et al. (February 2001). "Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study". Lancet 357 (9256): 592–8.  
  3. ^ Giralt M, Domingo P, Guallar JP, et al. (2006). "HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy.". Antivir Ther 11 (6): 729–40.  
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.