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Mildred Cohn (July 12, 1913 – October 12, 2009)[1][2] was an American biochemist who furthered understanding of biochemical processes through her study of chemical reactions within animal cells. She was a pioneer in the use of nuclear magnetic resonance for studying enzyme reactions, particularly in Adenosine triphosphate (ATP).[3] She received the nation's highest science award, the National Medal of Science, in 1982.[4]
Cohn's parents, childhood sweethearts Isidore Cohn and Bertha Klein Cohn,[3] were Jewish. Her father was a rabbi. They left Russia for the United States around 1907. Mildred Cohn was born July 12, 1913 in the Bronx, where her family lived in an apartment. When Mildren was 13, her father moved the family to a Yiddish-speaking cooperative, Heim Gesellschaft, which strongly emphasized education, the arts, social justice, and the preservation of Yiddish culture.[5][6]
Cohn graduated from high school at 14.[7] She went on to attend Hunter College, which was both free and open to all qualified women, irrespective of race, religion or ethnic background.[8] She received her Bachelor's cum laude in 1931.[7] She managed to afford a single year at Columbia University, but was ineligible for an assistantship because she was a woman.[8] After receiving her master's degree in 1932, she worked for the National Advisory Committee for Aeronautics for two years.[7] Although she had a supportive supervisor, she was the only woman among 70 men, and was informed that she would never be promoted.[8] She subsequently returned to Columbia, studying under Harold Urey, who had just won the Nobel Prize.[9][10] She wrote her dissertation on oxygen isotopes and earned her Ph.D. in physical chemistry in 1938.[11]
With Urey's recommendation, Cohn was able to obtain a position as a research associate in the laboratory of St. Louis. There Cohn conducted post-doctoral studies on sulfur-amino acid metabolism using radioactive sulfur isotopes. Cohn pioneered the use of isotopic tracers to examine the metabolism of sulfur-containing compounds.[12] When du Vigneaud moved his laboratory to Cornell University Medical College in New York City, Cohn and her new husband, physicist Henry Primakoff, moved to New York as well.[8][13]
In 1946, divalent metal ions are involved in the enzymatic reactions of ADP and ATP by studying NMR spectra of the phosphorus nuclei and the structural change in the presence of various divalent ions. [12]
In 1958, she was promoted from research associate to associate professor.[8] In 1960, Cohn and her husband joined the University of Pennsylvania. Mildred was appointed as an associate professor of Biophysics and Physical Biochemistry, and became a full professor the following year.[2][13] In 1964, she became the first woman to receive the American Heart Association’s Lifetime Career Award, providing support until she reached age sixty-five.[15] In 1971, she was elected to the National Academy of Sciences.[8] In 1982, she retired from the faculty as the Benjamin Rush Professor Emerita of Physiological Chemistry.[13]
In the course of her career, Mildren Cohn worked with four Nobel laureates, who received three Nobel prizes:
Cohn wrote 160 papers, mostly on her primary research subject of using nuclear magnetic resonance to study ATP.[14] She received a number of honorary doctorates.
She won the American Chemical Society’s
Mildred Cohn was married to physicist Henry Primakoff from 1938 until his death in 1983.[4] They had three children, all of whom earned doctorates.[8] Mildren Cohn is quoted in Elga Wasserman’s book, The Door in the Dream: Conversations With Eminent Women in Science, as saying “My greatest piece of luck was marrying Henry Primakoff, an excellent scientist who treated me as an intellectual equal and always assumed that I should pursue a scientific career and behaved accordingly.”[1][8]
During her career, Cohn achieved several gender firsts: She was the first woman to be appointed to the editorial board of the Journal of Biological Chemistry, where she served as editor from 1958–63 and from 1968-73. She was also the first woman to become president of the American Society for Biochemistry and Molecular Biology, and the first female career investigator for the American Heart Association.[2][13] In 2009, she was inducted into the National Women's Hall of Fame in Seneca Falls, New York.[2][23]
She was presented with the National Medal of Science by President Ronald Reagan in 1983 for 'pioneering the use of stable isotopic tracers and nuclear magnetic resonance spectroscopy in the study of the mechanisms of enzymatic catalysis'.[22]
[21] in 1986.Chandler Medal She received Columbia University’s [7] in 1979.[20]
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