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Nereus Pharmaceuticals

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Title: Nereus Pharmaceuticals  
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Subject: List of companies headquartered in San Diego, Aderis Pharmaceuticals, Zonite Products Corporation, Qualitest, Cortex Pharmaceuticals
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Nereus Pharmaceuticals

Nereus Pharmaceuticals
Industry Pharmaceuticals
Founded San Diego, California, United States (1988)
Founder Michael A. Palladino, Kobi M. Sethna, Stan Fleming, William Fenical
Headquarters San Diego, California, United States
Key people
Michael A. Palladino Ph.D.(Scientific Co-founder, SVP and Chief Technology Officer) Kobi M. Sethna (President, CEO)[1]
Gary Shearman (Chairman of the Board)[2]
Number of employees

Nereus Pharmaceuticals is a marine microbial and other natural sources into small molecule human therapeutics.[4] The major disease area addressed by Nereus is cancer. As of 2008, Nereus has no marketed products and its operating funds have been secured through several rounds of preferred stock sales.[3]

Drug discovery

Until 2004, Nereus used methods licensed from the Fungi.[4] Since 2004, the company has focused on commercializing identified bioactive natural products.[4] As of mid-2007, two compounds were being examined in Phase I clinical trials: NPI-2358 and NPI-0052.[4]

  • Plinabulin (NPI-2358) is a halimide derivative, halimide itself having been isolated from a member of genus Aspergillus.[4][5] This compound appears to selectively disrupt tumour vasculature through interaction with microtubules.[4]
  • NPI-1342 (Acanthoic Acid analog, NPI-1302a-3) is a plant derived orally active small molecule that targets the NF_kB transcript factor pathway. It is significantly active against cancer and inflammatory diseases and is being developed for clinical testing in multiple myeloma and glioblastoma.
  • Salinosporamide A (NPI-0052) is a natural product of Salinispora tropica, a member of the bacterial family Micromonosporaceae that was first isolated in 2002 and taxonomically identified genetically in 2005.[6] NPI-0052 acts as a proteasome inhibitor.[4]


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  5. ^ US 6069146 
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