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Philippa Marrack

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Title: Philippa Marrack  
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Subject: John Kappler, William B. Coley Award, Paul Ehrlich and Ludwig Darmstaedter Prize, Colorado Women's Hall of Fame, Anna Lee Aldred
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Philippa Marrack

Philippa "Pippa" Marrack
Born (1945-06-18) 18 June 1945
Ewell, England
Institutions National Jewish Health
Alma mater Cambridge University
University of California, San Diego
Doctoral advisor Alan Munro
Known for T cells, autoimmune disease
Notable awards Louisa Gross Horwitz Prize (1995)
Dickson Prize (1996)
Spouse John W. Kappler

Philippa "Pippa" Marrack FRS (born 18 June 1945) is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome.[1] She collaborates with her husband, John W. Kappler.


Marrack was born in Ewell, England on 18 June 1945.[2] She completed both undergraduate and Ph.D. work at New Hall, Cambridge. To earn her Ph.D, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to work on T cells. She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado.

Significant papers

  • J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
  • P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
  • J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
  • J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).



  1. ^ Rennie, J. (1992) Profile: Philippa Marrack and John Kappler – Keeping It In the Family, Scientific American 267(2), 43-44.
  2. ^ Yount, Lisa (2007). "Marrack, Philippa". A to Z of Women in Science and Math (Rev. ed.). New York: Infobase Pub. p. 191.  
  3. ^ "Philippa Marack To Be Honored for Lifetime Achievement in Immunology", May 4, 2003.
  4. ^ AAI Award History
  5. ^ Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize", Nov. 2, 2005.

Further reading

  • HHMI Profile of work
  • "Becoming a Scientist", Philippa Marrack, HHMI
  • "Philippa Marrack Targets T Cells and Autoimmune Disease", ScienceWatch
  • Christine Bahls, "Philippa Marrack", 'The Scientist v.18, n.6, p. 13 (2004).
  • "Profile: Philippa Marrack", Nature Medicine, v.10, n.12.

External links

  • Kappler/Marrack Lab
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