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Tectorial membrane

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Tectorial membrane

Tectorial membrane (cochlea)
Section through the spiral organ of Corti. (Membrana tectoria labeled at center top.)
Section through the spiral organ of Corti. (Membrana tectoria labeled at center top.)
Details
Latin membrana tectoria ductus cochlearis
Identifiers
MeSH A09.246.631.246.292.906
Dorlands
/Elsevier
m_08/12522277
Anatomical terminology

The tectorial membrane (TM) is one of two acellular gels in the auditory teeth of Huschke with its inside edge attached to the spiral limbus. The marginal zone is the thickest (transversally) and is divided from the middle zone by Hensen's Stripe. It overlies the sensory inner hair cells and electrically-motile outer hair cells of the organ of Corti and during acoustic stimulation stimulates the inner hair cells through fluid coupling, and the outer hair cells via direct connection to their tallest stereocilia.

Contents

  • Structure 1
  • Function 2
  • Additional images 3
  • Notes 4
  • External links 5

Structure

The TM is a gel-like structure containing 97% water. Its dry weight is composed of

External links

  1. ^ Thalmann, I.; Thallinger, G.; Comegys, T.H.; Thalmann, R. (1986). "Collagen – The Predominant Protein of the Tectorial Membrane". ORL 48 (2): 107–115.  
  2. ^ Goodyear, Richard J.; Richardson, Guy P. (2002). "Extracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: Molecular and structural diversity". Journal of Neurobiology 53 (2): 212–227.  
  3. ^ Freeman, Dennis M.; Masaki, Kinuko; McAllister, Abraham R.; Wei, Jesse L.; Weiss, Thomas F. (2003). "Static material properties of the tectorial membrane: a summary". Hearing Research 180 (1-2): 11–27.  
  4. ^ Freeman, Dennis M.; Abnet, C.Cameron; Hemmert, Werner; Tsai, Betty S.; Weiss, Thomas F. (2003). "Dynamic material properties of the tectorial membrane: a summary". Hearing Research 180 (1-2): 1–10.  
  5. ^ Richter, C; Emadi, G; Getnick, G; Quesnel, A; Dallos, P (2007). "Tectorial Membrane Stiffness Gradients☆". Biophysical Journal 93 (6): 2265–2276.  
  6. ^ Gueta, R.; Barlam, D.; Shneck, R. Z.; Rousso, I. (2006). "Measurement of the mechanical properties of isolated tectorial membrane using atomic force microscopy". Proceedings of the National Academy of Sciences 103 (40): 14790–14795.  
  7. ^ a b Ghaffari, R.; Aranyosi, A. J.; Freeman, D. M. (2007). "Longitudinally propagating traveling waves of the mammalian tectorial membrane". Proceedings of the National Academy of Sciences 104 (42): 16510–16515.  
  8. ^ a b Jones, Gareth; Russell, Ian; Lukashkin, Andrei; Shera, Christopher A.; Olson, Elizabeth S. (2011). "Laser Interferometer Measurements of the Viscoelastic Properties of Tectorial Membrane Mutants". pp. 419–420.  
  9. ^ Legan, P.Kevin; Lukashkina, Victoria A.; Goodyear, Richard J.; Kössl, Manfred; Russell, Ian J.; Richardson, Guy P. (2000). "A Targeted Deletion in α-Tectorin Reveals that the Tectorial Membrane Is Required for the Gain and Timing of Cochlear Feedback". Neuron 28 (1): 273–285.  
  10. ^ Legan, P Kevin; Lukashkina, Victoria A; Goodyear, Richard J; Lukashkin, Andrei N; Verhoeven, Kristien; Van Camp, Guy; Russell, Ian J; Richardson, Guy P (2005). "A deafness mutation isolates a second role for the tectorial membrane in hearing". Nature Neuroscience 8 (8): 1035–1042.  
  11. ^ a b Russell, Ian J; Legan, P Kevin; Lukashkina, Victoria A; Lukashkin, Andrei N; Goodyear, Richard J; Richardson, Guy P (2007). "Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane". Nature Neuroscience 10 (2): 215–223.  
  12. ^ Ghaffari, Roozbeh; Aranyosi, Alexander J.; Richardson, Guy P.; Freeman, Dennis M. (2010). "Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice". Nature Communications 1.  
  13. ^ a b Meaud, Julien; Grosh, Karl (2010). "The effect of tectorial membrane and basilar membrane longitudinal coupling in cochlear mechanics". The Journal of the Acoustical Society of America 127 (3): 1411.  

Notes

Additional images

The mechanical role of the tectorial membrane in hearing is yet to be fully understood, and traditionally was neglected or downplayed in many models of the cochlea. However, recent genetic[9][10][11] , mechanical[7][8][12] and mathematical[13] studies have highlighted the importance of the TM for healthy auditory function in mammals. Mice that lack expression of individual glycoproteins exhibit hearing abnormalities, including, most notably, enhanced frequency selectivity in Tecb−/− mice,[11] which lack expression of β-tectorin. In vitro investigations of the mechanical properties of the TM have demonstrated the ability of isolated sections of TM to support travelling waves at acoustically relevant frequencies. This raises the possibility that the TM may be involved in the longitudinal propagation of energy in the intact cochlea.[13]

Function

properties. [8][7]viscoelastic and to exhibit [6][5]anisotropic They have been experimentally shown to be radially and longitudinally [4] its mechanical properties are consequently significantly more complex.[3][2]

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