World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Alu Recombination-mediated Structural Deletions in the Chimpanzee Genome, Volume 3

By Trask, Barbara J.

Click here to view

Book Id: WPLBN0003924480
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Alu Recombination-mediated Structural Deletions in the Chimpanzee Genome, Volume 3  
Author: Trask, Barbara J.
Volume: Volume 3
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Trask, B. J. (n.d.). Plos Genetics : Alu Recombination-mediated Structural Deletions in the Chimpanzee Genome, Volume 3. Retrieved from http://ebook2.worldlibrary.net/


Description
Description : With more than 1.2 million copies, Alu elements are one of the most important sources of structural variation in primate genomes. Here, we compare the chimpanzee and human genomes to determine the extent of Alu recombination-mediated deletion (ARMD) in the chimpanzee genome since the divergence of the chimpanzee and human lineages (:6 million y ago). Combining computational data analysis and experimental verification, we have identified 663 chimpanzee lineage-specific deletions (involving a total of :771 kb of genomic sequence) attributable to this process. The ARMD events essentially counteract the genomic expansion caused by chimpanzee-specific Alu inserts. The RefSeq databases indicate that 13 exons in six genes, annotated as either demonstrably or putatively functional in the human genome, and 299 intronic regions have been deleted through ARMDs in the chimpanzee lineage. Therefore, our data suggest that this process may contribute to the genomic and phenotypic diversity between chimpanzees and humans. In addition, we found four independent ARMD events at orthologous loci in the gorilla or orangutan genomes. This suggests that human orthologs of loci at which ARMD events have already occurred in other nonhuman primate genomes may be ‘‘at-risk’’ motifs for future deletions, which may subsequently contribute to human lineage-specific genetic rearrangements and disorders.

 

Click To View

Additional Books


  • Plos Genetics : Time-lapse Analysis and ... (by )
  • Plos Genetics : Mitochondrial Morphogene... (by )
  • Plos Genetics : Maternal Expression Rela... (by )
  • Plos Genetics : Found ; the Elusive Anta... (by )
  • Plos Genetics : Copy Number Variation of... (by )
  • Plos Genetics : High-resolution Mapping ... (by )
  • Plos Genetics : Genome-wide Testing of P... (by )
  • Plos Genetics : a Pax3, Volume 6 (by )
  • Plos Genetics : Mutations in Hedgehog Ac... (by )
  • Plos Genetics : Identification of New Ge... (by )
  • Plos Genetics : Human Disease-associated... (by )
  • Plos Genetics : Understanding Mammalian ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.