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Plos Genetics : a Glial Variant of the Vesicular Monoamine Transporter is Required to Store Histamine in the Drosophilavisual System, Volume 4

By Dolph, Patrick J.

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Book Id: WPLBN0003925858
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : a Glial Variant of the Vesicular Monoamine Transporter is Required to Store Histamine in the Drosophilavisual System, Volume 4  
Author: Dolph, Patrick J.
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
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Publisher: Plos

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Dolph, P. J. (n.d.). Plos Genetics : a Glial Variant of the Vesicular Monoamine Transporter is Required to Store Histamine in the Drosophilavisual System, Volume 4. Retrieved from http://ebook2.worldlibrary.net/


Description
Description : Unlike other monoamine neurotransmitters, the mechanism by which the brain’s histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. We have studied the visual system of Drosophila melanogaster in which histamine is the primary neurotransmitter released from photoreceptor cells. We report here that a novel mRNA splice variant of Drosophila VMAT (DVMAT-B) is expressed not in neurons but rather in a small subset of glia in the lamina of the fly’s optic lobe. Histamine contents are reduced by mutation of dVMAT, but can be partially restored by specifically expressing DVMAT-B in glia. Our results suggest a novel role for a monoamine transporter in glia that may be relevant to histamine homeostasis in other systems.

 

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