World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Role of Transposon-derived Small Rnas in the Interplay Between Genomes and Parasitic Dna in Rice, Volume 8

By Ferguson-smith, Anne C.

Click here to view

Book Id: WPLBN0003942056
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Role of Transposon-derived Small Rnas in the Interplay Between Genomes and Parasitic Dna in Rice, Volume 8  
Author: Ferguson-smith, Anne C.
Volume: Volume 8
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Ferguson-Smith, A. C. (n.d.). Plos Genetics : Role of Transposon-derived Small Rnas in the Interplay Between Genomes and Parasitic Dna in Rice, Volume 8. Retrieved from http://ebook2.worldlibrary.net/


Description
Description : RNA silencing is a defense system against ‘‘genomic parasites’’ such as transposable elements (TE), which are potentially harmful to host genomes. In plants, transcripts from TEs induce production of double-stranded RNAs (dsRNAs) and are processed into small RNAs (small interfering RNAs, siRNAs) that suppress TEs by RNA–directed DNA methylation. Thus, the majority of TEs are epigenetically silenced. On the other hand, most of the eukaryotic genome is composed of TEs and their remnants, suggesting that TEs have evolved countermeasures against host-mediated silencing. Under some circumstances, TEs can become active and increase in copy number. Knowledge is accumulating on the mechanisms of TE silencing by the host: however, the mechanisms by which TEs counteract silencing are poorly understood. Here, we show that a class of TEs in rice produces a microRNA (miRNA) to suppress host silencing. Members of the microRNA820 (miR820) gene family are located within CACTA DNA transposons in rice and target a de novo DNA methyltransferase gene, OsDRM2, one of the components of epigenetic silencing. We confirmed that miR820 negatively regulates the expression of OsDRM2. In addition, we found that expression levels of various TEs are increased quite sensitively in response to decreased OsDRM2 expression and DNA methylation at TE loci. Furthermore, we found that the nucleotide sequence of miR820 and its recognition site within the target gene in some Oryza species have co-evolved to maintain their base-pairing ability. The co-evolution of these sequences provides evidence for the functionality of this regulation. Our results demonstrate how parasitic elements in the genome escape the host’s defense machinery. Furthermore, our analysis of the regulation of OsDRM2 by miR820 sheds light on the action of transposon-derived small RNAs, not only as a defense mechanism for host genomes but also as a regulator of interactions between hosts and their parasitic elements.

 

Click To View

Additional Books


  • Plos Genetics : Origination of an X-link... (by )
  • Plos Genetics : Transcriptional Control ... (by )
  • Plos Genetics : Continuous Requirement f... (by )
  • Plos Genetics : Atxn2-cag42 Sequesters P... (by )
  • Plos Genetics : Huntingtin Interacting P... (by )
  • Plos Genetics : Dynamic Circadian Protei... (by )
  • Plos Genetics : Genome Sequence of the P... (by )
  • Plos Genetics : H2A.Z Acidic Patch Coupl... (by )
  • Plos Genetics : Novel Association of Abo... (by )
  • Plos Genetics : Pre-mrna Secondary Struc... (by )
  • Plos Genetics : Elevated Proteasome Capa... (by )
  • Plos Genetics : Combinatorial Regulation... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.