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Plos Pathogens : Host Genetics and Hiv-1 ; the Final Phase, Volume 6

By Fellay, Jacques

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Book Id: WPLBN0003956675
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Pathogens : Host Genetics and Hiv-1 ; the Final Phase, Volume 6  
Author: Fellay, Jacques
Volume: Volume 6
Language: English
Subject: Journels, Science, Pathogens
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Pathogens
Publication Date:
Publisher: Plos


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Fellay, J. (n.d.). Plos Pathogens : Host Genetics and Hiv-1 ; the Final Phase, Volume 6. Retrieved from

Description : This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained : genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.


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