World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : the Wnt Gatekeeper Sfrp4 Modulates Emt, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells, Volume 7

By Samant, Rajeev

Click here to view

Book Id: WPLBN0003961599
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : the Wnt Gatekeeper Sfrp4 Modulates Emt, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells, Volume 7  
Author: Samant, Rajeev
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Samant, R. (n.d.). Plos One : the Wnt Gatekeeper Sfrp4 Modulates Emt, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells, Volume 7. Retrieved from http://ebook2.worldlibrary.net/


Description
Description : Aberrant Wnt signalling is implicated in numerous human cancers, and understanding the effects of modulation of pathway members may lead to the development of novel therapeutics. Expression of secreted frizzled related protein 4 (SFRP4), an extracellular modulator of the Wnt signalling pathway, is progressively lost in more aggressive ovarian cancer phenotypes. Here we show that recombinant SFRP4 (rSFRP4) treatment of a serous ovarian cancer cell line results in inhibition of bcatenin dependent Wnt signalling as measured by TOP/FOP Wnt reporter assay and decreased transcription of Wnt target genes, Axin2, CyclinD1 and Myc. In addition, rSFRP4 treatment significantly increased the ability of ovarian cancer cells to adhere to collagen and fibronectin, and decreased their ability to migrate across an inflicted wound. We conclude that these changes in cell behaviour may be mediated via mesenchymal to epithelial transition (MET), as rSFRP4 treatment also resulted in increased expression of the epithelial marker E-cadherin, and reduced expression of Vimentin and Twist. Combined, these results indicate that modulation of a single upstream gatekeeper of Wnt signalling can have effects on downstream Wnt signalling and ovarian cancer cell behaviour, as mediated through epithelial to mesenchymal plasticity (EMP). This raises the possibility that SFRP4 may be used both diagnostically and therapeutically in epithelial ovarian cancer.

 

Click To View

Additional Books


  • Plos One : the Calcitonin and Glucocorti... (by )
  • Plos One : the Prp19 Complex Directly Fu... (by )
  • Plos One : Cryptosporidium Parvuminfecti... (by )
  • Plos One : How to Make a Dolphin ; Molec... (by )
  • Plos One : Endotoxin Neutralization as a... (by )
  • Plos One : Influence of Approach Velocit... (by )
  • Plos One : Brain Activation Patterns at ... (by )
  • Plos One : Complete Solubilization and P... (by )
  • Plos One : Molecular Epidemiology and Ph... (by )
  • Plos One : Diversity of Plant Methionine... (by )
  • Plos One : a Robotics-based Behavioral P... (by )
  • Plos One : Deregulated Nras Expression i... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.