World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Pathogens : Mechanisms of Candida Albicans Trafficking to the Brain, Volume 7

By Cowen, Leah E.

Click here to view

Book Id: WPLBN0003962866
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Pathogens : Mechanisms of Candida Albicans Trafficking to the Brain, Volume 7  
Author: Cowen, Leah E.
Volume: Volume 7
Language: English
Subject: Journels, Science, Pathogens
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Pathogens
Publication Date:
Publisher: Plos


APA MLA Chicago

Cowen, L. E. (n.d.). Plos Pathogens : Mechanisms of Candida Albicans Trafficking to the Brain, Volume 7. Retrieved from

Description : During hematogenously disseminated disease, Candida albicans infects most organs, including the brain. We discovered that a C. albicans vps51D/D mutant had significantly increased tropism for the brain in the mouse model of disseminated disease. To investigate the mechanisms of this enhanced trafficking to the brain, we studied the interactions of wild-type C. albicans and the vps51D/D mutant with brain microvascular endothelial cells in vitro. These studies revealed that C. albicans invasion of brain endothelial cells is mediated by the fungal invasins, Als3 and Ssa1. Als3 binds to the gp96 heat shock protein, which is expressed on the surface of brain endothelial cells, but not human umbilical vein endothelial cells, whereas Ssa1 binds to a brain endothelial cell receptor other than gp96. The vps51D/D mutant has increased surface expression of Als3, which is a major cause of the increased capacity of this mutant to both invade brain endothelial cells in vitro and traffic to the brain in mice. Therefore, during disseminated disease, C. albicans traffics to and infects the brain by binding to gp96, a unique receptor that is expressed specifically on the surface of brain endothelial cells.


Click To View

Additional Books

  • Plos Pathogens : the E3 Ubiquitin Ligase... (by )
  • Plos Pathogens : Novel Strategy to Preve... (by )
  • Plos Pathogens : Interferon Regulatory F... (by )
  • Plos Pathogens : High-resolution Functio... (by )
  • Plos Pathogens : Evidence for a Wattle a... (by )
  • Plos Pathogens : Compensatory Evolution ... (by )
  • Plos Pathogens : a Heparan-dependent Her... (by )
  • Plos Pathogens : Two Group a Streptococc... (by )
  • Plos Pathogens : Inactivation of Staphyl... (by )
  • Plos Pathogens : Amp-activated Kinase Re... (by )
  • Plos Pathogens : Human Monoclonal Antibo... (by )
  • Plos Pathogens : Dc-sign and Cd150 Have ... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.